Arilin  KOMBIPACK 12 tablets +6 globules

What is the active ingredient?
1 film-coated tablet comprises as active ingredient, 250 mg of metronidazol.1 vaginal suppository comprising as active ingredient 100mg metronidazole
 
Drugs form and pharmacotherapeutic group: 
What Arelin Kombipak?
Pack of 12 pieces. coated tablets for oral administration and 6 pcs. pessaries for vaginal administration. 
 
5. Indications
For the treatment of trichomoniasis in women and men.
Notes:
Trichomoniasis is an infection caused by a microorganism called Trichomonas vaginalis, which most frequently leads to inflammation of the vagina and of the male urethra. Transmitted most often sexually. For the diagnosis of infection has to be taken for secretion smear.
 
6. Contraindications:
When you must not take Arelin ® Kombipak?
You should not take Arelin ® Kombipak in hypersensitivity to Metronidazole, and / or other 5-nitroimidazoIes, as well as to certain excipients. Anyway, if you have impaired liver blood count, brain, spinal cord or neurological razstroystva.Arilin Kombipak used only on prescription.
What you should consider during pregnancy and lactation?
In the first three months of pregnancy Arelin Kombipak should not be accepted. / If pregnancy is suspected to be a pregnancy test / During the second and third trimesters of pregnancy, Arelin Kombipak prescribed only if there are no other treatments.
Treatment with Arelin Kombipak during lactation should be discontinued and milk pumped and discarded as Arelin Kombipak passes into breast milk.
7. Precautions and usage tips
What should I observe when using Arelin Kombipak?
It should not consume alcohol during therapy, as may occur as signs of intolerance flushing of the head and neck, nausea, vomiting, headache and vertigo.
 
What should I keep in mind while working with machinery?
At the beginning of treatment Arelin Kombipak can slow reactions to sudden and unexpected events. Responses are not fast enough and targeted. Therefore, you should avoid driving vehicles and working with tools and machinery. At work should be provided strong support. Should not drink alcohol because it more namalyavareaktsionnata ability.
 
What else you should consider?
In trichomoniasis frequent winner of trihomonite is intimate partner, even if you do not notice changes in his health. Therefore, in trichomoniasis is necessary parallel treatment of intimate partner Arelin Kombipak otherwise possible reinfection. Preparachitelno is on during treatment to avoid sexual intercourse.
 
8. Interactions
What medicines affect the operation of Arelin Kombipak?
In applying vaginal suppositories Arelin, approximately 20% of the active ingredient Metronidazole passes into кръвообращението.Едновременното adoption of disulfiram can cause psychosis and conditions obarkanost.Deystvieto of Arelin decreases when co-administered with barbiturates (drugs containing active ingredients such as heksobarbiton or phenobarbitone, used in the treatment of sleep disorders and convulsions, and anesthesia), or when it is used together with drugs comprising phenytoin (medicines for the treatment of convulsions). Cimetidine (used in gastritis, gastric ulcer or intestine) may in single cases hinder the elimination of Metronidazole and thus increase the effect of Arelin. the action of other drugs which affect Arelin Kombipak? Patients treated with anticoagulants warfarin type, it should be borne in mind that the metronidazole enhances the anticoagulant effect. Upon acceptance of lithium (used in certain manic depression), and treatment with metronidazole observed increase in the concentration of lithium in blood serum and the risk of lithium toxicity, accompanied by tremors and spasms.
 
9. Dosage and method of administration
Please note that the coated tablets and vaginal suppositories have different administration.
How often and how much you should take daily Arelin Kombipak?
By combining was coated tablets containing metronidazole package whose dosage is determined by the type and severity of infection in each individual patient. The daily dose is displayed by your doctor. Without his knowledge should not make changes.
 
When and how you should take coated tablets of Arelin Kombipak?
Unless otherwise prescribed recommended the following dosing: The daily dose may amount to 1 to 8 coated tablets (= 0.25 g to 2.0 dMetronidazole) 2-3 times dnevno.Pri trichomoniasis is necessary to accept a lesser amount - 2 tablets (= 0,5 g Metronidazole), but for 5-7 dni.Po higher dose of 4 to 8 tablets (= 1g to 2g Metronidazole) daily duration of 1-3 days is considered dostatachna.Trihomoniaza may is treated with a single dose of coated tablets of 8 (= 2 g Metronidazole). coated tablets are taken with a meal or after a desired amount of water.
 
How often and how much vaginal suppositories should be administered daily?
Please follow the instructions for applying vaginal suppositories Arelin Kombipak.1 issue. of vaginal suppositories Arelin Kombipak place every night for six days in vlagalishteto.Nay better vaginal suppositories are placed in a supine position, with legs slightly. To further facilitate their application is thoroughly immediately before placing to be moistened with a little water. It is not recommended vaginal suppositories to apply during the menstrual cycle.
 
How and when should you take coated tablets in the packaging of Arelin Kombipak?
Coated tablets with a sufficient amount of water during meals or shortly thereafter.
 
How long should I take Arelin ® Kombipak?
The duration of treatment with Arelin Kombipak ® is determined by the attending physician. As a rule, the treatment with vaginal suppositories continued for 6 days.
 
warning:
As a rule, treatment with Arelin ® Kombipak or any other medicine containing nitroimidazole should not last more than 10 days. This period may be extended only in rare cases, if absolutely necessary, after the most rigorous assessment of evidence. Treatment should be repeated as much as possible rarely. Limitation of the duration of treatment necessary due to the inability to exclude damage to human gametes. / Possible genetic disorders / and an increase in some tumors in experimental animal studies.
10. Errors in use and overdose
What to keep in mind if you take a large amount of no-tablets and vaginal suppositories Arelin Kombipak?
If you take one dose twice Arelin Kombipak coated tablets, it should not affect the subsequent route of administration, ie you can continue with the next dose tablets Arelin Kombipak.V case of overdose can occur as side effects: nausea, vomiting, hyperreflexia, ataxia (difficulty in coordinating movements), attack of shortness of breath, disorientation, palpitations. There is no known antidote. After medical attention, the complaints were resolved after a few days. If vaginal suppositories be swallowed by a child, it should not lead to severe poisoning. If symptoms occur, they may disappear after a few days of treatment.
 
What to keep in mind if you take a small amount of Arelin Kombipak or stepropusnali another dose coated tablets and / or vaginal suppositories?
If you notice missing on the same day may further take the missed dose. If failure is detected after a few days, you may need treatment to be extended by one more day. Please consult your doctor.
What you should consider if you interrupt treatment prematurely Arelin Kombipak?
If you stop prematurely or stop for a while treatment with Arelin Kombipak may be endangered effectiveness of treatment.
 
11. Side Effects
What side effects may occur with the use of Arelin Kombipak? Upon application of vaginal suppositories approximately 20% of the active ingredient Metronidazole passes into the bloodstream. Therefore, may occur on the same side effects as well as the adoption of coated tablets, however the side effects of vaginal suppositories combined package occur much ryadko.Pri adoption of coated tablets incidence of side effects is razlichna.Ryadko common side effects:
• Metallic taste, bitter belching, coated tongue, sore mouth / glossitis, stomatitis / heaviness in the stomach, nausea, vomiting, anorexia, diarrhea;
• Headache, dizziness, insomnia; confusion, frustration, depressive disorder, ataxia;
• Peripheral neuropathies and seizure attacks. The first consist of numbness, paresthesia and numbness in kraynitsite.Dori if these symptoms are mild, you should inform your doctor immediately.
• Skin reactions (eg itching, hives), drug fever;
• Decrease in white blood cells (leucopenia and granulocytopenia). Therefore, prolonged administration should be monitored periodically blood count.
• Dark urine (not a sign of illness);
Rarely seen in regular use:
• Acute, persistent diarrhea during treatment. It may be due to the particular type of inflammatory bowel disease (colitis psevdomemfanozen) that require immediate treatment.
• rapid onset hypersensitivity reactions (anaphylactic reactions to a degree of anaphylactic shock). For milder cases may occur redness, allergic rhinitis and allergic conjunctivitis. If there are disturbances in the circulation with loss of consciousness, cold sweats, pale skin and cold extremities, should immediately seek medical attention. As she arrives, the upper body should be held horizontally with legs raised. To avoid the cold, the patient pulled the blanket.
• Dysuria, cystitis, urinary incontinence.
• functional disorders of the liver.
• superinfection with Candida in the genital area
• fatigue, visual disturbances.
Very rare side effects:
• Reduction of platelets (thrombocytopenia)
• Lack of certain white blood cells (agranulocytosis). Agranulocytosis may occur during the first few hours. Symptoms are fever, depression and inflammation of the tonsils. In these cases you need to quickly make a blood count and do consult your nearest doctor.
• Inflammation of the pancreas
If you notice any side effects not listed above, Turn around to your doctor or pharmacist.
What steps you should take in case of side effects?
If you notice signs of the above side effects, call your doctor.
12. Instructions and data for the shelf life of the drug
The expiry date is printed on the lid of the carton and tube. Do not use the drug after expiry date. Keep out of reach of children at temperature not exceeding 25 ° C.
 
13. Excipients
What else contain Arelin Kombipak?
Potato starch, lactose monohydrate, polyethylene glycol 6000, corn starch, magnesium stearate, oligo [butyl methacrylate-co-(2-dimethylaminoethyl) methacrylate-co-methyl methacrylate], povidone (K90), micronized silica, stearic acid, talc, titanium dioxide (E 171). If you have further questions, please ask your doctor or pharmacist.